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antagonize 
1 aggravate  (informal) alienate, anger, annoy, be on one's back  (slang) disaffect, estrange, gall, get in one's hair  (informal) get on one's nerves  (informal) get on one's wick  (Brit. slang) get under one's skin  (informal) get up one's nose  (informal) hassle  (informal) insult, irritate, nark  (Brit., Austral., & N.Z. slang) offend, piss one off  (taboo slang) repel, rub (someone) up the wrong way  (informal) 
2 contend with, counteract, neutralize, oppose, struggle with, work against 
 
Antonyms  
 
1 appease, calm, conciliate, disarm, mollify, pacify, placate, propitiate, soothe, win over 



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