1 a city in N central New Mexico, capital of the state: one of the oldest European settlements in North America, founded in 1610 as the capital of the Kingdom of New Mexico; developed trade with the U.S. by the Santa Fe Trail in the early 19th century. Pop.: 62514 (1994 est.)
2 (Spanish) an inland port in E Argentina, on the Salado River: University of the Littoral (1920). Pop.: 406388 (1991)
Santa Fean adj, n
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